To better evaluate the relationship between the two, this study selected for meta-analysis the internationally published clinical control case studies on p53 gene polymorphism and female endometriosis prevalence from 2001 to 2022 and systematically evaluated the relationship between p53 gene polymorphism and endometriosis prevalence, in order to provide more evidence-based medical data for revealing the internal relationship between gene polymorphism and endometriosis prevalence. Here, TP53 is linked to endometriosis.