In the TCGA database, we found 41 paired clinical samples show increased expression of PFDN1 (41/51); 49 paired clinical samples show increased expression of PFDN2 (49/51); 49 paired clinical samples show increased expression of VBP1 (49/51); 43 paired clinical samples show increased expression of PFDN4 (43/51); 42 paired clinical samples show increased expression of PFDN5; 49 paired clinical samples show increased expression of PFDN6 in HCC tissues. The gene discussed is PFDN2; the disease is hepatocellular carcinoma.