Higher expression of PFDN1 (HR = 1.49, 95% CI: 1.05–2.10, p = 0.025), PFDN2 (HR = 1.49, 95% CI: 1.05–2.11, p = 0.024), VBP1 (HR = 1.47, 95% CI: 1.03–2.08, p = 0.031), and PFDN4 (HR = 1.78, 95% CI: 1.25–2.53, p = 0.001) was significantly associated with shorter OS of liver cancer patients. This evidence concerns the gene PFDN1 and liver cancer.