The Oncomine analysis also indicated that PFDN3/4 was significantly overexpressed in HCC tissues, with fold changes of 2.364 and 2.758 and p-value of 4.76E-66 and 6.50E-71, in the Roessler Liver 2 dataset (Roessler et al., 2010). Here, VBP1 is linked to hepatocellular carcinoma.