HCC patients expressing higher levels of the PFDN1 (HR = 1.35, 95% CI: 1.01–1.81, p = 0.043), VBP1 (HR = 1.38, 95% CI: 1.03–1.85, p = 0.031), and PFDN4 (HR = 1.45, 95% CI: 1.08–1.94, p = 0.013) transcripts experienced significantly shorter PFI. The gene discussed is PFDN4; the disease is hepatocellular carcinoma.