As the important members of AGE-RAGE pathway, Tgfb1 was known as the predominant profibrotic factor that drived glomerular and tubulointerstitial fibrosis in different types of kidney diseases (López-Hernández and López-Novoa, 2012), and Col1a1 was a crucial fibrotic gene in ECM formation and fibroplasia of RF (Hosper et al., 2013). Here, RENBP is linked to kidney disorder.