The in vivo data indicated that glomerulosclerosis, severe collagen deposition, enhanced expressions of biomarkers (TGF-β1 and α-SMA), reduction of E-cadherin biomarkers, and significant renal function changes (significantly decreased UTP, CREA, Ccr, and ALB levels and increased UUN and BUN levels) occurred in both adenine- and UUO-induced models. Here, TGFB1 is linked to glomerulosclerosis.