The International Myeloma Working Group (IMWG) defines the diagnostic criteria for MGUS as less than 3 g/dL of M-protein in the serum, less than 10% monoclonal plasma cells in the bone marrow, and no CRAB criteria (elevated calcium, renal insufficiency, anemia, or lytic bone lesions) [14]. This evidence concerns the gene MYOM2 and plasma cell myeloma.