However, the results of TLE1 immunohistochemistry (IHC) studies in pancreatic and lung cancer tissue samples showed that TLE1 was mainly distributed in the nucleus, even though constitutive MAPK activation was prominent in these two cancer types (Allen et al., 2006; Wang et al., 2020); therefore, whether MAPK regulates the nuclear localization of TLE1 in certain tumors in vivo remains to be verified. The gene discussed is TLE1; the disease is cancer.