TLE1 is frequently upregulated and may function as an oncogene in certain cancer types, such as NSCLC, invasive breast cancer, and GMB (Allen et al., 2006; Brunquell et al., 2012; Holmes et al., 2012; Verginelli et al., 2013; Yao et al., 2014a; Yao et al., 2016; Lee et al., 2017). The gene discussed is TLE1; the disease is cancer.