In addition, TLE5 may recruit HDAC3 to the promoter of Notch target genes in colorectal cancer cells to suppress transcription, and interestingly, these effects depend on unique TLE complexes formed by TLE1 and TLE5 in the nucleus (Sonoshita et al., 2011; Itatani et al., 2016). The gene discussed is TLE5; the disease is colorectal cancer.