In glioblastoma (GMB), the expression of TLE1 is upregulated and associated with a poor prognosis; further studies revealed that TLE1 forms a complex with FOXG1 to inhibit the expression of CHAC1, a negative regulator of the Notch signaling pathway, resulting in overactivation of the Notch signaling pathway and accelerated GMB progression (Figure 2) (Verginelli et al., 2013; Dali et al., 2018). Here, TLE1 is linked to glioblastoma.