TLE1 and chronic myelogenous leukemia, BCR-ABL1 positive: Fraga et al. found that the CpG island in the TLE1 gene promoter is frequently hypermethylated, causing epigenetic inactivation of TLE1 in various blood tumor cells, including AML, chronic myeloid leukemia (CML), and non-Hodgkin’s lymphoma (Fraga et al., 2008).