TLEs are also involved in estrogen receptor (ER) and androgen receptor (AR) signaling pathways (Nakaya et al., 2007; Jangal et al., 2014; Stelloo et al., 2018), and both pathways provide important survival signaling for cancer cells expressing these receptors (Aurilio et al., 2020; Belachew and Sewasew, 2021). Here, ESR1 is linked to cancer.