Fraga et al. found that the CpG island in the TLE1 gene promoter is frequently hypermethylated, causing epigenetic inactivation of TLE1 in various blood tumor cells, including AML, chronic myeloid leukemia (CML), and non-Hodgkin’s lymphoma (Fraga et al., 2008). The gene discussed is TLE1; the disease is non-Hodgkin lymphoma.