For example, TLE1 was reported to interact with NOD2 and thus inhibit NF-κB signaling, and TLE1 gene mutation or reduced TLE1 expression was found to be associated with the pathogenesis of inflammatory bowel disease and hepatic ischemia/reperfusion injury (Nimmo et al., 2011; Chen et al., 2020). Here, TLE1 is linked to ischemia.