In addition to its anti-inflammatory actions, beneficial effects of 10Panx1 were shown in Panx1-mediated platelet aggregation (Molica et al., 2019), α-adrenergic vasoconstriction (Billaud et al., 2011), Panx1-related HIV replication (Seror et al., 2011) and breast cancer metastasis in mice (Furlow et al., 2015). Here, PANX1 is linked to breast cancer.