Already in 2006, ischemia-like conditions such as oxygen/glucose deprivation have been shown to open a large conductance (530 pS) channel in neurons (later identified as Panx1), which is involved in excitotoxicity and neuronal death during stroke (Thompson et al., 2006; Thompson and Macvicar, 2008; Weilinger et al., 2012; Weilinger et al., 2016). This evidence concerns the gene PANX1 and Stroke.