Anatomical and histological observation also found that the up-regulation of proBDNF/mBDNF ratio induced synaptic plasticity impairment, and cognitive decline in depressive episodes and aged (Diniz et al., 2018; Wang et al., 2021), indicating BDNF has bidirectional effects on neuronal function depending on the cleavage of proBDNF (Barnes and Thomas, 2008; Menshanov et al., 2015; Wang et al., 2021). Here, BDNF is linked to Mental deterioration.