Additionally, the hypofunction of calcineurin in schizophrenia animals, which displayed dysfunction in BDNF trafficking (Pineda et al., 2009; Suh et al., 2013), had the potential to alter synaptic plasticity and memory behavior and result in profound disruptions of information processing (Miyakawa et al., 2003; Cottrell et al., 2013; Tamura et al., 2018). Here, BDNF is linked to schizophrenia.