RND3 and myalgic encephalomeyelitis/chronic fatigue syndrome: To further discern the role of Rnd3 in fibrosis, CFs were isolated from neonatal mice and cultured at different concentrations of glucose (5; 25; 30; 35 mmol/L) and palmitic acid (PA; 500 μmol/L) to induce glycotoxicity and lipotoxicity in vitro (Figure S3A-B).