By contrast, the lung capillary permeability and MVD were markedly decreased in the tumor-bearing mice injected with MDA-MB-231 and NFs (MDA-MB-231/NFs Ctrl) or CAFs with shRNA against lncSNHG5 and ZNF281 (CAFs/sh lncSNHG5, CAFs/shZNF281), or CAFs with inhibitors RS102895 or Maraviroc or Cenicriviroc (CAFs/RS102895, CAFs/Maraviroc, CAFs/Cenicriviroc), and the ZO-1 and Occludin levels were increased in these groups. The gene discussed is OCLN; the disease is neoplasm.