Compared with the tumor-bearing mice injected with MDA-MB-231 cells and CAFs, the tumor-bearing mice injected with the mixture of MDA-MB-231 cells and NFs or CAFs with shRNA against lncSNHG5 and ZNF281 (CAF/sh lncSNHG5, CAF/shZNF281) or CAFs with inhibitors RS102895 or marviroc or cenicriviroc (CAFs/RS102895, CAFs/Maraviroc, CAFs/Cenicriviroc) had fewer and smaller lung metastases, whereas overexpression of ectopic ZNF281 in the lncSNHG5-knockdown CAFs (CAFs/sh lncSNHG5/ZNF281) rescued the lung metastases (Figure 8A-C). This evidence concerns the gene ZNF281 and neoplasm.