Rhodamine-dextran was intravenously injected into tumor-bearing mice to assess lncSNHG5-mediated vascular permeability in vivo, and fluorescent staining was performed to determine the levels of vascular markers CD31 and tight junction proteins ZO-1 and Occludin in lung tissue to reflect the angiogenesis and permeability changes of lung blood vessels. Here, TJP1 is linked to neoplasm.