The reduced number and size of pulmonary metastatic nodules in animal groups injected with ITGA5 KO2 LIU-LSC-1 cells were also partially rescued by overexpression of EFNB2, as confirmed by macroscopic observation, hematoxylin and eosin (H&E) staining of pulmonary tissues, and scaling of the average lung weight of tumor-bearing mice (Figure 6I-L). Here, ITGA5 is linked to neoplasm.