IHC staining also showed that tumor sections from nude mice that had been injected subcutaneously with ITGA5 KO2 LIU-LSC-1 cells expressed less EFNB2 protein, while ITGA5 OE TU177 cells showed a higher expression level of EFNB2 (Figure 4F). This evidence concerns the gene EFNB2 and neoplasm.