In this study, 10 m6A-associated pseudogenes were confirmed as promising prognostic indicators for HNSCC by a comprehensive analytical framework and classified into oncogene pseudogenes (PDIA3P1, LDHAP4, LDHAP7, EEF1A1P6, EEF1A1P11) and tumor-suppressor pseudogenes (SDHAP1, SDHAP3, DDX12P, CLUHP3, RRN3P3) owing to their different effects in prognosis in TCGA dataset. This evidence concerns the gene RRN3P3 and head and neck squamous cell carcinoma.