To experimentally test whether the m6A-associated pseudogenes affect the expression of their targeted immune-involved genes, we selected representative oncogene pseudogene PDIA3P1 and tumor-suppressor pseudogene RRN3P3 for further validation in ARO and Tca8113 cell lines, which were two representatives HNSCC cell lines. Here, RRN3P3 is linked to head and neck squamous cell carcinoma.