Through assessing the immune cell infiltration, we found that the low-risk subtype had a prominently higher number of tumor-infiltrating B cells, CD8+ T cells (as known as cytotoxic T cells), helper T cells, regulatory T cells, and a lower fraction of activated natural killer cells, M1 macrophage cells, M2 macrophage cells than high-risk (Figure 3B), suggesting an enhanced immunosurveillance in the low-risk subtype. This evidence concerns the gene CD8A and neoplasm.