It's worth noting that WTAP, YTHDC1, and YWHAG represented significant differences both in TCGA and in the GEO dataset, implying the critical function of m6A regulators in HNSCC, in line with the pivotal roles of YTHDC1 and WTAP in the previous findings (Figure 1E). Here, YTHDC1 is linked to head and neck squamous cell carcinoma.