For example, compared to normal tissues, the expressions of METTL3, METTL14, WTAP, VIRMA, ZCCHC4, FTO, ALKBH5, YTHDC1, YTHDF1, YTHDF2, YTHDF3, HNRNPC, HNRNPD, RBM15, RBM27, ZC3H7B, YWHAG, CAPRIN1 and PCIF1 increased significantly in tumor tissues, while the expressions of YTHDC2, ZC3H7B, TRA2A, GNL3, and MSI2 decreased (Figure S2). The gene discussed is ALKBH5; the disease is neoplasm.