Our findings firstly revealed that the expression pattern of the 10 m6A-associated pseudogenes was dramatically associated with tumor-infiltrating B cells, CD8+ T cells, helper T cells, and regulatory T cells, as well as the expressions of T cell exhausted markers including PD-1, PD-L1, PD-L2, LAG3, TIGIT, and CTLA4. What's more, antigen presentation genes, interferon activity genes, cytolytic genes, integrin genes, and kinase genes were also significantly associated with pseudogenes levels. Here, TIGIT is linked to neoplasm.