MT-ND2 and medulloblastoma: To further evaluate the potency of SIAIS361034 in combating the resistance to Smo inhibitors in vivo, we isolated the spontaneous medulloblastoma from ND2:SmoA1 transgenic mice, which carry a mutation of Smo W539L under the control of ND2 promoter 38, and allografted them into the nude mice.