Nude mice harboring ND2:SmoA1 medulloblastoma were treated with SIAIS361034 or GDC-0449 as indicated in Figure 6A. The tumor growth was remarkably suppressed by administration with SIAIS316034, resulting in 93.56% mean tumor growth inhibition (TGI) ratio at the termination of the experiment. Here, MT-ND2 is linked to neoplasm.