In recurrent cSCC, effector CD8+ T cells exhibited high expression levels of HAVCR2 (TIM3) and CXCL13, while CD8+ cytotoxic T cells displayed high expression levels of CTLA4 and CXCL13 and relatively higher expression levels of LAG3 (Figure 3E). Here, CTLA4 is linked to skin squamous cell carcinoma.