CD8A and neoplasm: Complement activation can produce anaphylatoxins (including C3a and C5a), which can cause an inflammatory response and recruit neutrophils 18, 54, possibly explaining why neutrophils but not other immune cells, such as NK cells, CD8+ T cells, B cells, dendritic cells and macrophages, were quickly recruited closer to tfRFP-B16 cells in the tfRFP-immunized mice (Figure 8A and Figure S12A-B) and engaged in ADCC to kill tumor cells.