By directly targeting and antagonizing multiple binding partners, including collagens, thrombospondin-1, multiple receptor tyrosine kinases, growth factors, proteases and other enzymes, and Toll-like receptors (TLRs), DCN is involved in regulating collagen fibrillogenesis, angiostasis, tumor growth, autophagy, and immune responses, making it the “guardian from the matrix” 11. Here, DCN is linked to neoplasm.