GIT2 and type 2 diabetes mellitus: And this was supported by the following studies, GIT2 was identified as a hub gene to connect with the aging process and aging-related diseases (35); as metabolic status influences aging, Martin et al. (36) deleted GIT2 and found it altered transcriptomic signatures of the hypothalamus, which affects type II diabetes and metabolic pathways; GIT2 is also highly responsive to oxidative stress (37); TB, as the end product of heme degradation, can improve the endothelial function of MS through inhibiting oxidative stress.