By taking important genes with specificity in NB as entry points, the scope of downregulated candidate genes was narrowed down, and it included PHOX2B [26, 27], MYCN [28], ZMYND8, XPOT, LIN28B [29], TERT [30], and other important genes (Figure 6(b)). The gene discussed is XPOT; the disease is neuroblastoma.