CDK5 and bone cancer: Besides its involvement in inflammatory pain, Cdk5 has been also shown to modulate several other kinds of pain such as neuropathic pain (Li K. et al., 2014; Yang et al., 2014), bone cancer pain (Zhang R. et al., 2012), visceral pain (Chang et al., 2011), post-operative pain (Liu et al., 2014), orofacial pain (Prochazkova et al., 2013; Hu et al., 2022).