In vivo tumorigenesis experiments performed by Chai showed that exosomal lnc-ROR1-AS1 promoted glioma development by inhibiting the miR-4686 axis, indicating that upregulating the expression of exosomal lnc-ROR1-AS1 could alleviate the progression of glioma (Chai et al., 2020). This evidence concerns the gene ROR1 and central nervous system cancer.