Overall, a panel of markers that includes the base model and CST-C (total protein ratio), IL-1RN (total protein ratio), MMP-9 (total protein ratio) and total protein (μg/mL) could distinguish either MCI or AD from the CN controls with an AUC = 0.97 (95%CI 0.94–1.00). This evidence concerns the gene IL1RN and Alzheimer disease.