PINK1 and Mental deterioration: For example, EOPD with PRKN, PINK1, or DJ-1 mutations are characterized by good response to L-dopa treatment, dystonia and dyskinesia being relatively common, cognitive decline relatively uncommon and a slower deterioration of the disease when compared with idiopathic PD (Kasten et al., 2018; Lin et al., 2019; Zhao et al., 2020; Sun et al., 2021).