Neurological diseases such as AD can inhibit the production of brain-derived IL-8, while inflammatory cytokines such as IL-1β and TNF-α produced by inflammation caused by neurological diseases can further induce the production of IL-8 by endothelial cells and neutrophils, leading to inflammatory chemotaxis and thus aggravating the damage of this region. The gene discussed is IL1B; the disease is Alzheimer disease.