When Sato et al. (2018) compared tau half-life in 12 Alzheimer subjects to 12 controls, tau half-life was longer in the Alzheimer subjects (31.5 ± 4.0 days) than the control subjects (29.4 ± 6.0 days), consistent with slowed tau catabolism in Alzheimer's disease. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.