MAPT and early-onset autosomal dominant Alzheimer disease: There is growing interest in how tau is catabolized in the Alzheimer's disease (de Vrij et al., 2004; Chesser et al., 2013; Tarasoff-Conway et al., 2015; Vaz-Silva et al., 2018; Xin et al., 2018; Liu et al., 2021).