Apolipoprotein E (APOE), inositol polyphosphate-5-phosphatase D (INPP5D), cluster of differentiation 33 (CD33), and phospholipase C gamma 2 (PLCG2) have been identified as high-risk genes in AD and have been linked to Aβ accumulation in AD mouse models (Sierksma et al., 2020). This evidence concerns the gene APOE and Alzheimer disease.