Although it is possible to detect Aβ plaques and tau-related neurodegeneration by imaging and from analytes in the cerebrospinal fluid (Jack and Holtzman, 2013), about 40% of nondemented normal elderly people show AD neuropathology including senile plaques and neurofibrillary tangles (Jack and Holtzman, 2013); conversely, some clinically diagnosed AD cases exhibit no neuropathologic features of the disease (Beach et al., 2012). Here, MAPT is linked to Alzheimer disease.