Another study showed that immune reactivity of TrxR1 was observed in more than 50% of recurrent oligodendrogliomas, 1.5 times that of primary oligodendrogliomas, indicating that TrxR1 acts positively in the malignant progression of oligodendrogliomas (Järvelä et al., 2006). Here, TXNRD1 is linked to oligodendroglioma.