To assess whether hub genes could predict HNSCC patient survival, we used the univariate Cox regression method to filter candidate prognostic genes, including CD2, SH2D1A, TBC1D10C, CD3E, CD3G, CD247, SLA2, SIRPG, CXCR3, CD96, CD7, and ARHGAP9 (Figure 3A). This evidence concerns the gene CD2 and head and neck squamous cell carcinoma.