Although previous studies pointed out its antitumor immunogenicity through CD8+ T cells, recent research proved that immune-mediated tumor control by necroptotic fibroblasts requires nuclear factor κB (NF-κB) activation within dying cells but not MLKL-mediated and cell lysis-dependent DAMP release (Snyder, et al., 2019). The gene discussed is CD8A; the disease is neoplasm.