CASP8 and neoplasm: We found that 21 of the 48 PRGs were differentially expressed (logFC >0.5, FDR <0.05) in the TCGA dataset consisting of 59 normal and 535 tumor tissues; 10 genes were downregulated (IL-1β, NLRC4, CASP5, IRF1, CASP1, NLRP3, NEK7, P2RX7, MEFV, and IRF1), while the remaining were upregulated (CASP8, GSDME, CASP3, CASP6, GSDMA, GSDMB, NLRP7, GSDMC, ZBP1, IFI16, and AIM2).