Based on published ICD-related literature (Garg et al., 2016; Galluzzi et al., 2020), we identified 21 ICD-related genes (ATG5, CALR, CASP1, CASP8, CD4, CD8A, CXCR3, EIF2AK3, HSP90AA1, IFNGR1, IL17RA, IL1B, IL1R1, LY96, MYD88, NLRP3, P2RX7, PIK3CA, PRF1, TLR4, TNF) and analyzed their expression differences between BC and normal samples. The gene discussed is CD8A; the disease is breast cancer.