The characteristic expression patterns of m5C-related lncRNAs were associated with MGMT promoter methylation, epithelial mesenchymal transition (Zhang et al., 2022), tumor immune response, and cell cycle disruption and hypoxia (Zhou et al., 2022), and it may also alter the sensitivity of tumor cells to TMZ-induced cytotoxic effects (Rajesh et al., 2020; Zhang et al., 2022). Here, MGMT is linked to neoplasm.