NSUN5 and central nervous system cancer: Wang et al. (2020) constructed a risk signature to predict prognosis in patients with glioma. They found that high expression of NOP2, NSUN4, NSUN5, and NSUN7 was linked to poor prognosis, whereas high expression of NSUN6 was linked to better prognosis (Li and Meng, 2021). The ability of NSUN2 to regulate cell migration by promoting mRNA cytosine methylation has been demonstrated in the brain cancer cell line U87 (Xu et al., 2020c; Wang et al., 2020).