NSUN2 and neoplasm: NSUN2 also plays an important role in chemoresistance of tumors, as inhibition of post-transcriptional RNA cytosine methylation modifications can lead to a general decrease in intracellular protein synthesis by activating stress response pathways, and this inhibition makes tumor stem cells sensitive to cytotoxic stress and unable to regenerate and proliferate under chemotherapy drug stress (Blanco et al., 2016).