Another study in 2020 provided further clarification about the molecular mechanisms of FTO’s influence on the reaction of glioma cells to TMZ; this may work increasing the stability and translation efficiency of Myc and then participating in regulating the MYC-miR-155/23a Cluster-MXI1 feedback circuit, which is related to the proliferation and tumorigenesis of gliomas (Xiao et al., 2020). Here, MXI1 is linked to central nervous system cancer.