TNFRSF11A and osteoporosis: Moreover, its binding ability is stronger than RANKL (Simonet et al., 1997), which can effectively interfere with the combination of RANKL and RANK. Common OPG polymorphisms associated with osteoporosis risk include A163G (rs3102735), T950C (rs2073617), and T245G (rs3134069), which are located at the promoter of the gene, while G1181C (rs2073618) is located at the first exon of the gene.