In the sex subgroup, the OPG A163G polymorphism can significantly increase the risk of osteoporosis in females (G vs A: OR = 1.30, 95% CI = 1.03–1.64; AG + GG vs AA: OR = 1.42, 95% CI = 1.18–1.71, Table 1 and Figure 2). This evidence concerns the gene TNFRSF11B and osteoporosis.