At the same time, the OPG G1181C polymorphism reduces the risk of osteoporosis (C vs G: OR = 0.84, 95% CI = 0.74–0.95; CC vs GG: OR = 0.75, 95% CI = 0.60–0.93; GC + CC vs GG: OR = 0.80, 95% CI = 0.67–0.95; CC vs GG + GC: OR = 0.84, 95% CI = 0.70–1.00). This evidence concerns the gene TNFRSF11B and osteoporosis.