TNFRSF11B and osteoporosis: In addition, there are many candidate genes (VDR, TGFB1, COL1A1, and OPG), but the association of these polymorphisms with osteoporosis risk has not been thoroughly demonstrated (Prestwood et al., 1995; Jørgensen et al., 2012; Saccone et al., 2015; Tsukasaki et al., 2020).