TNFRSF11B and osteoporosis: When only control studies that met HWE and high-quality scores were retained, we found that in the overall analysis, the OPG A163G polymorphism significantly increases the risk of osteoporosis (G vs A: OR = 1.40, 95% CI = 1.16–1.68; GG vs AA: OR = 1.96, 95% CI = 1.20–3.21; AG + GG vs AA: OR = 1.45, 95% CI = 1.22–1.72, Table 1), and the same was observed in the female population (G vs A: OR = 1.39, 95% CI = 1.14–1.70; GG vs AA: OR = 1.96, 95% CI = 1.15–3.35; AG + GG vs AA: OR = 1.42, 95% CI = 1.17–1.72, Table 1).