TNFRSF11B and osteoporosis: However, when we retained only studies in the control group that was consistent with Hardy-Weinberg equilibrium (HWE) and high-quality scores, we observed that the OPG A163G polymorphism increased the risk of osteoporosis in the overall analysis (G vs A: OR = 1.40, 95% CI = 1.16–1.68; GG vs AA: OR = 1.96, 95% CI = 1.20–3.21; AG + GG vs AA: OR = 1.45, 95% CI = 1.22–1.72).