TNFRSF11B and osteoporosis: A total of 31 studies (Figure 1) were included in our study (including 8,402 osteoporosis cases and 7,517 controls), of which 14 studies reported OPG A163G (2,379 cases and 2,229 controls), nine studies investigated OPG T245G (941 cases and 1,019 controls), 12 studies investigated OPG T950C (1,610 cases and 1,234 controls), and 18 studies reported OPG G1181C (3,472 cases and 3,035 controls), as shown in Supplementary Table 1.