Although the expression of ERBB2 was positively correlated with that of TSHR, the role of TSHR in radioiodine refractoriness remains debated because the highly expressed TSHR is not only associated with high radioiodine uptake (Hou et al., 2010) but also causes fast thyroid tumor growth (Lu et al., 2010). The gene discussed is ERBB2; the disease is thyroid tumor.