Based on the analysis of 43 prognostic genes of mutation data in the TCGA database, 18 genes, namely XXYLT1, STT3B, POMGNT2, GXYLT1, B4GALT5, B4GALT3, B4GALT2, B3GNTL1, B3GAT3, B3GALNT1, ALG3, TMTC3, TMEM165, MOGS, PIGZ, PIGM, EXT2, and MUC6 were mutated in HCC. This evidence concerns the gene TMEM165 and hepatocellular carcinoma.