Based on the analysis of 43 prognostic genes of mutation data in the TCGA database, 18 genes, namely XXYLT1, STT3B, POMGNT2, GXYLT1, B4GALT5, B4GALT3, B4GALT2, B3GNTL1, B3GAT3, B3GALNT1, ALG3, TMTC3, TMEM165, MOGS, PIGZ, PIGM, EXT2, and MUC6 were mutated in HCC. The gene discussed is QTGAL; the disease is hepatocellular carcinoma.