Based on the analysis of 43 prognostic genes of mutation data in the TCGA database, 18 genes, namely XXYLT1, STT3B, POMGNT2, GXYLT1, B4GALT5, B4GALT3, B4GALT2, B3GNTL1, B3GAT3, B3GALNT1, ALG3, TMTC3, TMEM165, MOGS, PIGZ, PIGM, EXT2, and MUC6 were mutated in HCC. The gene discussed is B3GAT3; the disease is hepatocellular carcinoma.