Table 2 shows the details of the 41 vital targets. The PPI network generated 41 nodes, which represent proteins, and 552 edges which represent the connections between proteins. The larger node means the greater degree (Figure 5(b)). Furthermore, the top 10 targets ranked by MCC using the cytoHubba plug-in were IL-6, SRC, CTNNB1, STAT3, CASP3, TNF, EGFR, MAPK8, HSP90AA1, and PTGS2 (Figure 5(c)) and selected as core targets for interaction with NSCLC. The gene discussed is MAPK8; the disease is non-small cell lung carcinoma.