TLR4/NF-κB constitutes the classical inflammatory signaling pathway, can play crucial roles in mediating immune and inflammatory responses, and participate in the pathological process of EMs [21, 22]; furthermore, autophagy was thought to be regulated via TLR4/NF-κB signaling pathway [23, 24]. This evidence concerns the gene NFKB1 and eosinophilia-myalgia syndrome.