Importantly, the association of concomitant expression of INPP5A/IL-10 and INPP5A/MMP-21 in tumors with advanced stage (III) compared to the early stages (I and II) was statistically significant (p < 0.001), suggesting that the co-expression pattern of INPP5A with HLA-G1, IL-10, and MMP-21 are dependent on these aggressive tumor features. The gene discussed is MMP21; the disease is neoplasm.