As shown in Table 5, co-overexpression of HLA-G1/IL-10 and HLA-G1/MMP-21 genes was correlated with an increased ESCC stage, and HLA-G1 and IL-10 (p = 0.052) were remarkably correlated with the stage III (Table 5). The gene discussed is IL10; the disease is esophageal squamous cell carcinoma.