Indeed, eEF1A dimethylation in H. pylori-negative mucosa with adenocarcinoma of the fundic gland type, which is known to be unrelated to H. pylori infection, was as low as those in H. pylori-negative and cancer-free mucosa (data not shown), supporting our hypothesis that H. pylori infection might cause aberrant protein methylation. This evidence concerns the gene EEF1A1 and cancer.