Five substances were up-regulated in HCC cell-derived exosomes, including ephrin-B2 (EfnB2), delta-like 4 ligand (DLL4), angiopoietin-2 (Ang2), circ-100338, and Vasorin (VASN), which have been verified to have links with active endothelium-dependent angiogenesis. Here, DLL4 is linked to hepatocellular carcinoma.