For example, in a study in 2010, it was found that miR-375 enrichment in MCC-derived exosomes can cause downregulation the expression of two key factors of recombination signal binding protein for immunoglobulin kappa J region (RBPJ) and Tumor protein p53 (TP53) in fibroblast polarization. Here, TP53 is linked to Merkel cell skin cancer.