Compared with healthy controls, CYP4V2 rs1398007 was associated with an increased risk for IS patients with hypertension (OR = 1.50, 95% CI 1.14–1.96, p = 0.008; OR = 1.40, 95% CI 1.08–1.82, p = 0.010), while it exerted a protective effect on IS patients without hypertension (OR = 0.37, 95% CI 0.15–0.88, p = 0.031). The gene discussed is CYP4V2; the disease is hypertensive disorder.