AGER and Alzheimer disease: For example, increased uptake of amyloid peptides via Receptor for Advanced Glycation End-products (RAGE) and reduced clearance from the brain via the active efflux transporters of amyloid peptides, p-glycoprotein (P-gp), and LDL receptor–related protein 1 (LRP1), contribute to the amyloid burden pathognomonic of AD [37].