PLAGL2 and central nervous system neoplasm: Here, we utilized a broad genome-wide DNA methylation cohort, combined with copy number profiling, targeted next-generation DNA sequencing, and RNA sequencing, to identify a rare CNS tumor type characterized by amplification and overexpression of either PLAGL1 (located at chromosome 6q24.2) or PLAGL2 (located at chromosome 20q11.21).