One tumor with PLAGL2 amplification (#A113—excluded from the core DNA methylation cohort due to QC issues, but with a clear signal for ET, PLAGL), harbored additional focal high-level amplifications of the MDM4 oncogene on chromosome 1q32.1 and the MYCN oncogene on chromosome 2p24.3. This evidence concerns the gene MDM4 and neoplasm.