Sedentary behavior and obesity do not only have detrimental short- and long-term effects on physical (e.g., cardiovascular disease, high fasting insulin levels/ type-2 diabetes, metabolic syndrome, cancer, musculoskeletal disorders)60–63 and mental health (e.g., depression, stress, anxiety, low self-esteem)64,65 but also on the quality of sleep. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.