PRG4 and congenital bilateral aplasia of vas deferens from CFTR mutation: By analyzing the transcriptome of aortic valves of CAVD patients, we identified altered expression of several genes which are shared by patients with or without CHIP, these include genes already known for their role in CAVD and related to the extracellular matrix and osteo-chondrocyte transition such as TNC, PRG4, COL11A1, SMOC2, FN1, and OGN21,27,28.