In addition to HL60 (with mutation of NRAS, M2) and MV4–11 (with mutation of FLT3, M5), 8GL could induce differentiation in other AML cell lines, such as OCI-AML3 (with mutation of DNMT3A, M4) and THP1 (with mutation of CDKN2A, M5) (Supplemental Fig. S4F, G). This evidence concerns the gene RUNX2 and acute myeloid leukemia.