The development of telomerase inhibitors, in general, raises several questions: (i) some studies have shown that the ALT (alternative lengthening of telomere) mechanism may be activated as an adaptive response to telomerase inhibition leading to chemoresistance; (ii) clinical relevance of telomerase inhibition in cancer patients is controversial due to the delayed therapeutic effect (i.e., the lag time needed for telomeres to shorten to a critical size before a cancer cell undergoes senescence and/or cell death) [46, 47]. The gene discussed is GPT; the disease is cancer.