We found that the gavage of KLPJ did not cause colitis in caspase-1/11 KO mice and KLPJ also did not promote DSS-mediated colitis in these caspase-1/11 KO mice (Figure 8); whereas their littermates with or without KLPJ gavage were markedly different not only in non–DSS-treated mice (Figure 8A–D) but also in DSS-mediated colitis (Figure 8E–L). Here, CASP1 is linked to colitis.