A transgenic animal model for FDD (Tg-FDD) expressing the Danish mutant form of human BRI2 under the control of the mouse prion protein promoter shows significant vascular and parenchymal ADan deposition, amyloid associated gliosis, intracellular and extracellular deposition of oligomeric forms of ADan, as well as tau immunoreactive deposits in the neuropil (10). Here, ITM2B is linked to ADan amyloidosis.