To assess the effect of ApoE on ADan deposition in an in vivo model of amyloidosis, we generated mice in which the Danish mutant form of human BRI2 is expressed under the control of the mouse prion protein promoter (Tg-FDD) (10) on an ApoE KO (ApoE−/−) background (Tg-FDD+/−/ApoE−/−). This evidence concerns the gene ITM2B and amyloidosis.