Point mutations in the stop codon of BRI2 cause FBD and familial Chinese dementia (2, 4), while FDD is caused by a 10-nucleotide duplication insertion (BRI2795-796InsTTTAATTTGT) in the 3′-end of the coding region of the BRI2 gene (3). Here, ITM2B is linked to ADan amyloidosis.