TBCE and colorectal carcinoma: Although CRC organotropism to the liver can be explained by the evident anatomic position of the portal vein, carrying blood directly from the gut to the liver, recent studies have highlighted an elegant mechanism, in which CRC-derived extracellular vesicles carrying nucleic acids and integrins fuse specifically with KCs in the liver, altering their gene expression and promoting the formation of a pre-metastatic niche.