Other chemokines such as CXCL1, CXCL2, and CCL2 can be secreted by TAMs, KCs, LSECs, and activated HSCs in the premetastatic liver, resulting in the recruitment of MDSCs that promoted CRC cell survival by suppressing CD8+ CTLs and inducing Treg cells [88]. The gene discussed is TBCE; the disease is colorectal carcinoma.