Previous studies investigated the function of cyclooxygenase enzyme 2 (COX-2), prostaglandin E2 (PGE2), and its receptors (EP) in many different tumor entities like colon cancer, prostate and lung cancers, as well as in breast cancer and gynecological tumors, such as ovarian, cervical, and endometrial cancers (Howe 2007; Wang and Dubois 2010a, 2010b; Ye et al. 2020). The gene discussed is PTGS2; the disease is neoplasm.