Interestingly, we did not find any significant association between tumor-infiltrating PD-1+TIM-3+, PD-1+TIGIT+, PD-1+ICOS+, and PD-1+LAG-3+ NK cells in TILs and NILs in CRC patients (Supplementary Fig. S1). The gene discussed is ICOS; the disease is colorectal carcinoma.