Basic leucine zipper and W2 domains 1 is an adaptor for protein kinase RNA-like endoplasmic reticulum kinase, which in turn facilitates the phosphorylation of eIF2α to promote internal ribosome entry site (IRES)-dependent translation of HIF1α and c-Myc in human pancreatic ductal adenocarcinoma [32]. This evidence concerns the gene MYC and pancreatic ductal adenocarcinoma.